This product was advertised heavily in Ohio and Illinois in 1853 and 1854. At that time, C.E. Fisher was listed as the proprietor. In 1856, I found Charles S. Emerson was listed as a Chemist, and Conrad E. Fisher listed as a Patent Medicine Proprietor in Cleveland. According to the label on the bottle, the product was marketed by C. E. Fisher & Co., 57 Superior Street, Cleveland. The following year, Emerson was listed as a Wheelwright, and Fisher was not listed at all. They must have been in business a very short time, and this bottle has got to be extremely rare.